Atualização científica relâmpago

Uso profilático da azitromicina em cesárea não eletiva. Estudo em 14 centros dos EUA, com 2013 cesáreas - estudo randomizado. 

Publicado em 29 set de 2016 no 

Adjunctive Azithromycin Prophylaxis for Cesarean Delivery

Alan T.N. Tita, M.D., Ph.D., Jeff M. Szychowski, Ph.D., Kim Boggess, M.D., George Saade, M.D., Sherri Longo, M.D., Erin Clark, M.D., Sean Esplin, M.D., Kirsten Cleary, M.D., Ron Wapner, M.D., Kellett Letson, M.D., Michelle Owens, M.D., Adi Abramovici, M.D., Namasivayam Ambalavanan, M.D., Gary Cutter, Ph.D., and William Andrews, M.D., Ph.D., for the C/SOAP Trial Consortium*

N Engl J Med 2016; 375:1231-1241September 29, 2016DOI: 10.1056/NEJMoa1602044

CONCLUSIONS

Among women undergoing nonelective cesarean delivery who were all receiving standard antibiotic prophylaxis, extended-spectrum prophylaxis with adjunctive azithromycin was more effective than placebo in reducing the risk of postoperative infection. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development; C/SOAP ClinicalTrials.gov number,NCT01235546.)

VEJA TAMBÉM O EDITORIAL

EDITORIAL

Antibiotic Prophylaxis for Cesarean Delivery — When Broader Is Better

R.A. Weinstein and K.M. Boyer

N Engl J Med 375:1284, September 29, 2016